General information:
Function | unspecified product (FBP) |
Gene type | Protein coding gene |
Transcript location | chr.04:426451-429433|- |
Alternative SL | 429419(2) |
Alternative polyA site | 426457(2),426459(1) |
Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.04.T1160 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.04.1160 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0005975,GO:0006094,GO:0020015,GO:0042578
Associated PubMed publications:
- Yuan M, Vasquez-Valdivieso MG, McNae IW, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD. 2017. Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. J Mol Biol 429: 3075-3089. [PUBMED]
- Naderer, T., Ellis, M.A., Sernee, M.F., De Souza, D.P., Curtis, J., Handman, E., and McConville, M.J. (2006). Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A 103, 5502-5507. [PUBMED]
- Saini S, Ghosh AK, Das S, Singh R, Abhishek K, Verma S, Kumar A, Mandal A, Purkait B, Sinha KK et al. 2018. Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity. Vaccine 36: 1190-1202. [PUBMED]