General information:
| Function | trypanothione reductase (TRYR) |
| Gene type | Protein coding gene |
| Transcript location | chr.05:105349-107695|+ |
| Alternative SL | 105569(4),105354(41),105358(17),105416(6),105470(21),105574(1),105480(1) |
| Alternative polyA site | 107711(2),107654(1),107640(1) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.05.T0350 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.05.0350 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0045454,GO:0055114,GO:0005737,GO:0015036,GO:0015042,GO:0016491,GO:0050660,GO:0070402
Associated PubMed publications:
- Brotherton MC, Bourassa S, Legare D, Poirier GG, Droit A, Ouellette M. 2014. Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum. Int J Parasitol Drugs Drug Resist 4: 126-132. [PUBMED]
- Mittal MK, Misra S, Owais M, Goyal N. 2005. Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli. Protein Expr Purif 40: 279-286. [PUBMED]
- Dumas C, Ouellette M, Tovar J, Cunningham ML, Fairlamb AH, Tamar S, Olivier M, Papadopoulou B. 1997. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. Embo J 16: 2590-2598. [PUBMED]