General information:
| Function | endonuclease G; putative |
| Gene type | Protein coding gene |
| Transcript location | chr.10:301319-303390|- |
| Alternative SL | 303610(4),303387(7) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.10.T0610 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.10.0610 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0046872,GO:0016787,GO:0003676
Associated PubMed publications:
- Rico E, Alzate JF, Arias AA, Moreno D, Clos J, Gago F, Moreno I, Dominguez M, Jimenez-Ruiz A. 2009. Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus. Mol Biochem Parasitol 163: 28-38. [PUBMED]
- Oliva C, Sanchez-Murcia PA, Rico E, Bravo A, Menendez M, Gago F, Jimenez-Ruiz A. 2017. Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences. Nucleic Acids Res 45: 9030-9045. [PUBMED]
- Rico E, Oliva C, Gutierrez KJ, Alzate JF, Genes CM, Moreno D, Casanova E, Gigante A, Perez-Perez MJ, Camarasa MJ et al. 2014. Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival. PLoS One 9: e89526. [PUBMED]