General information:
| Function | sterol 14-alpha-demethylase; putative (CYP51) |
| Gene type | Protein coding gene |
| Transcript location | chr.11:463873-468052|+ |
| Alternative SL | 463894(1) |
| Alternative polyA site | 467989(1) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.11.T1100 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.11.1100 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0008398,GO:0044091,GO:0055114,GO:0009055,GO:0020037,GO:0005506
Associated PubMed publications:
- Mwenechanya R, Kovarova J, Dickens NJ, Mudaliar M, Herzyk P, Vincent IM, Weidt SK, Burgess KE, Burchmore RJS, Pountain AW et al. 2017. Sterol 14alpha-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS neglected tropical diseases 11: e0005649. [PUBMED]
- Xu W, Hsu FF, Baykal E, Huang J, Zhang K. 2014. Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania. PLoS Pathog 10: e1004427. [PUBMED]
- McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR et al. 2015. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS neglected tropical diseases 9: e0003588. [PUBMED]