General information:
| Function | ornithine decarboxylase; putative |
| Gene type | Protein coding gene |
| Transcript location | chr.12:103996-106827|+ |
| Alternative SL | 104107(2) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
-
Here you can download sequence data derived from our research.
- LmjF.12.T0280 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.12.0280 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0003824,GO:0006596
Associated PubMed publications:
- Fonseca MS, Comini MA, Resende BV, Santi AM, Zoboli AP, Moreira DS, Murta SM. 2017. Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony. Exp Parasitol 175: 36-43. [PUBMED]
- Hanson S, Adelman J, Ullman B. 1992. Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani. J Biol Chem 267: 2350-2359. [PUBMED]
- Boitz JM, Yates PA, Kline C, Gaur U, Wilson ME, Ullman B, Roberts SC. 2009. Leishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host. Infect Immun 77: 756-763. [PUBMED]
- Haimeur A, Guimond C, Pilote S, Mukhopadhyay R, Rosen BP, Poulin R, Ouellette M. 1999. Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite- resistant Leishmania. Mol Microbiol 34: 726-735. [PUBMED]
- Jiang Y, Roberts SC, Jardim A, Carter NS, Shih S, Ariyanayagam M, Fairlamb AH, Ullman B. 1999. Ornithine decarboxylase gene deletion mutants of Leishmania donovani. J Biol Chem 274: 3781-3788. [PUBMED]